مشخصات مقاله:
عنوان فارسی مقاله:
یک مطالعه چند بخشی درمورد پاسخ سلامت عمومی به بیماری کبد چرب غیر الکلی در اروپا
عنوان انگلیسی مقاله:
A cross-sectional study of the public health response to non-alcoholic fatty liver disease in Europe
مناسب برای رشته های دانشگاهی زیر:
پزشکی
مناسب برای گرایش های دانشگاهی زیر:
گوارش و کبد، بهداشت عمومی
وضعیت مقاله انگلیسی و ترجمه:
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قسمتی از مقاله انگلیسی:
Introduction
Non-alcoholic fatty liver disease (NAFLD) is a growing challenge to global public health. It is defined as the increased accumulation of hepatic triglyceride (>5%) in the absence of excessive alcohol consumption or other causes of liver disease. The NAFLD spectrum encompasses steatosis (non-alcoholic fatty liver, NAFL) and non-alcoholic steatohepatitis (NASH), an inflammatory form of the condition marked by the presence of hepatocyte damage and progressive fibrosis that may lead to cirrhosis.1,2 Although NAFLD may occur in patients with normal weight, it is closely associated with the presence of the metabolic syndrome, and therefore with obesity, type 2 diabetes mellitus, hypertension and dyslipidaemia.3 The prevalence estimates of NAFLD vary widely according to the modality used to detect NAFLD and the geographical area.3,4 Most of the larger studies on NAFLD prevalence are based on ultrasonography,5 which is insensitive to modest increases in hepatic lipid accumulation at levels <30%, and do not employ diagnostic tools recommended by current guidance (e.g. transient elastography, NAFLD fibrosis score, magnetic resonance imaging, or the gold standard, liver biopsy).1 Nevertheless, a recent meta-analysis estimated the global prevalence of NAFLD to be 25%, with the highest estimates in the Middle East and South America (32% and 31%, respectively) and the lowest estimates in the African continent (14%); the estimates for Asia, the USA, and Europe were 27%, 24% and 23%, respectively.