مشخصات مقاله:
عنوان فارسی مقاله:
خطر افزایش یافته ابتلا به سرطان رکتوم ابتدایی دوم بعد از پرتودرمانی لگن
عنوان انگلیسی مقاله:
Increased risk for second primary rectal cancer after pelvic radiation therapy
کلمات کلیدی مقاله:
پرتو درمانی، سرطان رکتال، سرطان دوم، ناشی از تابش، سرطان، سرطان پروستات، سرطان آندومتری، سرطان دهانه رحم، سرطان واژن، سرطان تخمدان، سرطان مثانه
مناسب برای رشته های دانشگاهی زیر:
پزشکی
مناسب برای گرایش های دانشگاهی زیر:
گوارش و کبد، پرتوشناسی و راديولوژی
وضعیت مقاله انگلیسی و ترجمه:
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فهرست مطالب:
1. Introduction
2. Material and methods
2.1. Statistical analysis
3. Results
3.1. Standardised incidence ratios
3.2. Crude incidence ratio
3.3. Competing risk analysis
3.4. Characteristics of rectal cancer and survival analysis
4. Discussion
5. Conclusions
Conflict of interest statement
References
قسمتی از مقاله انگلیسی:
1. Introduction
Compared with the general population, cancer survivors have an increased risk of developing new malignancies [1,2]. This is the result of a combination of factors such as lifestyle, genetic susceptibility and type of treatment for their previous cancer [3,4]. Radiation therapy (RT) is part of the treatment regimen in at least 50% of all patients with cancer and has been associated with the development of second primary cancers [3e5]. However, recent studies have shown that in some cases, RT does not increase the risk for a second primary cancer and might even have a preventive effect [2,6,7]. When RT is administered for a tumour located in the pelvis, the rectum is likely to be within the irradiation field and is therefore prone to early and late toxicity [8,9]. Recently, a systematic review and metaanalysis on the incidence of second primary rectal cancer after RT for a primary pelvic tumour demonstrated a small increase in rectal cancer incidence after pelvic RT [10]. However, given the sparse evidence in the literature regarding several primary tumour sites (e.g., bladder and vaginal cancer), this hypothesis warrants further study and validation using population-based data. A second primary rectal cancer after RT to the pelvic region has implications for rectal cancer treatment. One of the difficulties is whether additional courses of RT can be given because reirradiation has been associated with an excess of toxicity [11]. In addition, it is not clear whether radiation-induced rectal cancer is equally sensitive to RT compared with a sporadic rectal cancer. Yet, recent studies suggest that reirradiation can be of added value and that toxicity seems to be acceptable [12e15]. In addition, fibrosis due to previous RT can be associated with more challenging surgery and possibly increased surgical complications [15,16]. As a result, there might be a difference in outcomes between patients with rectal cancer who did or did not receive RT as part of the treatment for their previous cancer located in the pelvis