مشخصات مقاله:
عنوان فارسی مقاله:
رویکردهای مهندسی بافت مبتنی بر چارچوب در معالجه ناباروری
عنوان انگلیسی مقاله:
Scaffold-based tissue engineering approaches in treating infertility
کلمات کلیدی مقاله:
مهندسی بافت، داربست، ناباروری
کلمات کلیدی انگلیسی:
Tissue engineering – Scaffold – Infertility
مناسب برای رشته های دانشگاهی زیر:
پزشکی
مناسب برای گرایش های دانشگاهی زیر:
مهندسی بافت، بیو لوژی تولیدمثل
وضعیت مقاله انگلیسی و ترجمه:
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فهرست مطالب:
Abstract
Graphical abstract
Keywords
1. Introduction
2. Regenerative medicine
3. Infertility
4. Female infertility
4.1. Tissue engineering application in uterine disorders treating
4.1.1. Scaffold-based tissue engineering approaches in treating intrauterine adhesion & Asherman syndrome
4.1.2. Scaffold-based tissue engineering approaches in treating thin endometrium
4.2. Scaffold-based tissue engineering approaches in treating ovulation disorders
4.2.1. Scaffold-based tissue engineering approaches in treating premature ovarian failure
4.3. Scaffold-based tissue engineering approaches in treating cervix disorders
5. Scaffold-based tissue engineering approaches in treating male infertility
6. Conclusion
Funding source
Author contribution to study
Declaration of competing interest
References
قسمتی از مقاله انگلیسی:
1. Introduction
Infertility threatens individual s’ psychological and physical stability and even social stability of specially young couples [1]. Although infertility is not considered a vital disease, but effect of this problem on all aspects of their personal and social lives is clearly seen. For couples suffering from infertility, mental problems such as depression, anxiety, lack of self-confidence and dissatisfaction with their lives are expected [2]. Infertile couples are exposed to different physical and emotional problems that naturally affect their marital and social status. Infertility can also leave effect on the relationship between infertile patients and their spouses, friends and colleagues [3,4]. Many structural abnormalities in male and female reproductive system can be affected by diseases, trauma and some of special therapies particularly cancer therapies which ultimately contribute to infertility. On the other hand, regenerative medicine and the use of scaffolds to treat these abnormalities have recently been taken as promising approaches to treat infertile young couples. The utilized scaffolds for this subject must be characterized as: biodegradable and biocompatible, inter-connectivity, macro porous 3D structure for cell culture, and also have appropriate mechanical properties for closely mimicking the natural Extra-Cellular Matrix (ECM) [5,6]. For transportation of food and waste materials and for cellular communication processes, the existence of interconnectivity is vital. For cell migration, adhesion, proliferation and metabolism, scaffolds must have suitable mechanical properties, and furthermore, for resistance and stability of the gels, mechanical properties play key roles [7–13]. Atala et al. [14], expanded and seeded the urothelial and muscle cells biopsies, obtained from end-stage bladder disease patients, on a scaffold to generate bladder constructs.